Generic Name: Amlodipine 5mg + Olmesartan Medoxomil 40mg
Manufacturer Distributor: ACI Limited
🛒 How to order this item?
100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
Show More
Indications
There are two medications in Abecab 5/40 that both work to lower blood pressure. Your likelihood of experiencing a heart attack or stroke in the future is decreased by lowering blood pressure.
Pharmacology
Amlodipine is a dihydropyridine calcium channel blocker that prevents calcium ions from crossing the blood-brain barrier and entering vascular smooth muscle and cardiac muscle. Compared to cardiac muscle cells, amlodipine has a stronger effect on vascular smooth muscle cells. Amlodipine is a peripheral artery vasodilator that reduces peripheral vascular resistance and blood pressure by acting directly on vascular smooth muscle.
Angiotensin II is a powerful vasoconstrictor, the principal vasoactive hormone of the Renin-angiotensin system, and an essential component in the pathogenesis of hypertension. It is generated from angiotensin I in a mechanism catalyzed by angiotensin-converting enzyme (ACE). It also causes the adrenal cortex to secrete more aldosterone.
By specifically blocking angiotensin II's binding to the AT1 receptor located in numerous tissues, Olmesartan Medoxomil reduces the vasoconstrictor and aldosterone-secreting effects of angiotensin II (e.g. vascular smooth muscle, adrenal gland). Olmesartan medoxomil is a reversible, competitive AT1 receptor inhibitor, according to in vitro binding tests.
Dosage & Administration
General considerations
Maximum antihypertensive effects are attained within 2 weeks. Abecab® may be taken with or without food. Abecab® may be administered with other antihypertensive agents. The dosage may be increased after 2 weeks. The maximum recommended dose of Abecab® is 2 tablets (10/40 mg) once daily.
Initial therapy
The usual starting dose of Abecab® is one tablet (5/20 mg) once daily. Depending on the blood pressure response, the dose may be titrated at intervals of 1-2 weeks to two tablets of Abecab® (10/40 mg) once daily.
Replacement therapy
Abecab® may be substituted for its individually titrated components. When substituting for individual components, the dose of one or both of the components can be increased if blood pressure control has not been satisfactory.
Add-on Therapy
Abecab® may be used to provide additional blood pressure lowering for patients not adequately controlled with Amlodipine (or another dihydropyridine calcium channel blocker) alone or with Olmesartan Medoxomil (or another Angiotensin receptor blocker) alone.
Elderly patients
No dosage adjustment is necessary for elderly patients ≥ 65 years of age.
Patients with hepatic impairment
Initial therapy with Abecab® is not recommended in patients≥75 years and in patients with hepatic impairment.
Interaction
In vitro data indicate that Amlodipine has no effect on the human plasma protein binding of digoxin, phenytoin, warfarin, and indomethacin. No significant drug interactions were reported when Olmesartan was co-administered with digoxin or warfarin.
Contraindications
A combination of Amlodipine and Olmesartan is contraindicated in patients who are hypersensitive to any component of this product or to any of its ingredients.
Side Effects
The overall incidence of side effects on therapy with the Amlodipine and Olmesartan combination was similar to that seen with corresponding doses of the individual components and to placebo. The common side effects include edema, hypotension, orthostatic hypotension, rash, pruritus, palpitation, urinary frequency, and nocturia.
Pregnancy & Lactation
Olmesartan medoxomil: Pregnancy Categories C (first trimester) and D (second and third trimesters). Amlodipine: There are no adequate and well-controlled studies in pregnant women. Amlodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. When pregnancy is detected, discontinue this Amlodipine and Olmesartan combination as soon as possible. It is not known whether Amlodipine or Olmesartan Medoxomil is excreted in human milk.
Precautions & Warnings
Caution should be exercised in patients with volume or salt depletion, severe aortic stenosis, severe obstructive coronary artery disease, congestive heart failure, impaired renal function, and hepatic impairment. No initial dosage adjustment is recommended for patients with moderate to marked renal impairment (Creatinine clearance).
Storage Conditions
Do not store at temperatures above 30°C. Keep out of the reach of youngsters and away from light.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.