Abecab 5/40mg 10pcs - ePharma
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Abecab 5/40mg 10pcs

Generic: Amlodipine

Type: Tablet

Pack Size: 10 Pcs

Generic Name: Amlodipine 5mg + Olmesartan Medoxomil 40mg
Manufacturer Distributor: ACI Limited 


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Discount Price: ৳ 188
MRP: ৳ 200 6% Off

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✅ Description:

Indications

There are two medications in Abecab 5/40 that both work to lower blood pressure. Your likelihood of experiencing a heart attack or stroke in the future is decreased by lowering blood pressure.

Pharmacology

Amlodipine is a dihydropyridine calcium channel blocker that prevents calcium ions from crossing the blood-brain barrier and entering vascular smooth muscle and cardiac muscle. Compared to cardiac muscle cells, amlodipine has a stronger effect on vascular smooth muscle cells. Amlodipine is a peripheral artery vasodilator that reduces peripheral vascular resistance and blood pressure by acting directly on vascular smooth muscle.

Angiotensin II is a powerful vasoconstrictor, the principal vasoactive hormone of the Renin-angiotensin system, and an essential component in the pathogenesis of hypertension. It is generated from angiotensin I in a mechanism catalyzed by angiotensin-converting enzyme (ACE). It also causes the adrenal cortex to secrete more aldosterone.

By specifically blocking angiotensin II's binding to the AT1 receptor located in numerous tissues, Olmesartan Medoxomil reduces the vasoconstrictor and aldosterone-secreting effects of angiotensin II (e.g. vascular smooth muscle, adrenal gland). Olmesartan medoxomil is a reversible, competitive AT1 receptor inhibitor, according to in vitro binding tests.

 

Dosage & Administration

General considerations

Maximum antihypertensive effects are attained within 2 weeks. Abecab® may be taken with or without food. Abecab® may be administered with other antihypertensive agents. The dosage may be increased after 2 weeks. The maximum recommended dose of Abecab® is 2 tablets (10/40 mg) once daily.

Initial therapy

The usual starting dose of Abecab® is one tablet (5/20 mg) once daily. Depending on the blood pressure response, the dose may be titrated at intervals of 1-2 weeks to two tablets of Abecab® (10/40 mg) once daily.

Replacement therapy

Abecab® may be substituted for its individually titrated components. When substituting for individual components, the dose of one or both of the components can be increased if blood pressure control has not been satisfactory.

Add-on Therapy

Abecab® may be used to provide additional blood pressure lowering for patients not adequately controlled with Amlodipine (or another dihydropyridine calcium channel blocker) alone or with Olmesartan Medoxomil (or another Angiotensin receptor blocker) alone.

Elderly patients

No dosage adjustment is necessary for elderly patients ≥ 65 years of age.

Patients with hepatic impairment 

Initial therapy with Abecab® is not recommended in patients≥75 years and in patients with hepatic impairment.

Interaction

In vitro data indicate that Amlodipine has no effect on the human plasma protein binding of digoxin, phenytoin, warfarin, and indomethacin. No significant drug interactions were reported when Olmesartan was co-administered with digoxin or warfarin.

 

Contraindications

A combination of Amlodipine and Olmesartan is contraindicated in patients who are hypersensitive to any component of this product or to any of its ingredients.

Side Effects

The overall incidence of side effects on therapy with the Amlodipine and Olmesartan combination was similar to that seen with corresponding doses of the individual components and to placebo. The common side effects include edema, hypotension, orthostatic hypotension, rash, pruritus, palpitation, urinary frequency, and nocturia.

Pregnancy & Lactation

Olmesartan medoxomil: Pregnancy Categories C (first trimester) and D (second and third trimesters). Amlodipine: There are no adequate and well-controlled studies in pregnant women. Amlodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. When pregnancy is detected, discontinue this Amlodipine and Olmesartan combination as soon as possible. It is not known whether Amlodipine or Olmesartan Medoxomil is excreted in human milk.

Precautions & Warnings

Caution should be exercised in patients with volume or salt depletion, severe aortic stenosis, severe obstructive coronary artery disease, congestive heart failure, impaired renal function, and hepatic impairment. No initial dosage adjustment is recommended for patients with moderate to marked renal impairment (Creatinine clearance).

Storage Conditions

Do not store at temperatures above 30°C. Keep out of the reach of youngsters and away from light.

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Check our pricing section for Abecab 5/40mg 10pcs price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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